FRACTAL STORM (SELF-LAID OPTIONS

From the LSD-certain crystal construction, the aspect chain in the lid residue L209EL2 kinds in depth hydrophobic contacts with the two LSD and surrounding residues in TMs III, IV, and V (Figure 4C). When the lid moved apart to expose the binding pocket in simulation, many of such contacts broke. We As a result hypothesized that L209EL2 functions b